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Page 1
The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males.
Tikkanen R, Saukkonen T, Fex M, Bennet H, Rautiainen MR, Paunio T, Koskinen M, Panarsky R, Bevilacqua L, Sjöberg RL, Tiihonen J, Virkkunen M. Tikkanen R, et al. J Psychiatr Res. 2016 Oct;81:79-86. doi: 10.1016/j.jpsychires.2016.06.019. Epub 2016 Jun 25. J Psychiatr Res. 2016. PMID: 27420381
A cohort of subjects belonging to a founder population that included 98 ASPD males, aged 25-30, was divided into groups based on the presence of a heterozygous 5-HT2B receptor loss-of-function gene mutation (HTR2B Q20*; n = 9) or not (n = 89). ...Reduced 5 …
A cohort of subjects belonging to a founder population that included 98 ASPD males, aged 25-30, was divided into groups based on the presenc …
Expression of serotonin receptors 5-HT1A, 5-HT1B, 5-HT2B and 5-HT4 in ovary and in ovarian tumours.
Henriksen R, Dizeyi N, Abrahamsson PA. Henriksen R, et al. Anticancer Res. 2012 Apr;32(4):1361-6. Anticancer Res. 2012. PMID: 22493371
In benign and non-invasive cancer cells, strong staining was seen, while in invasive cancer cells, decreased expression was observed. For 5-HTR2B, the decrease was correlated to dissemination of the disease. ...In the stromal part, a variable immunoreactivity was observed …
In benign and non-invasive cancer cells, strong staining was seen, while in invasive cancer cells, decreased expression was observed. For 5- …
Influence of a HTR2B Stop Codon on Glucagon Homeostasis and Glucose Excursion in Non-Diabetic Men.
Tikkanen R, Saukkonen T, Fex M, Bennet H, Rautiainen MR, Paunio T, Koskinen M, Panarsky R, Bevilacqua L, Sjöberg RL, Tiihonen J, Virkkunen M. Tikkanen R, et al. Exp Clin Endocrinol Diabetes. 2016 Oct;124(9):529-534. doi: 10.1055/s-0042-109263. Epub 2016 Jul 20. Exp Clin Endocrinol Diabetes. 2016. PMID: 27437919
Limited data are available about the role of the serotonin 2B (5-HT2B) receptor in the function of human islets. This study aimed to test whether the 5-HT2B receptor contributes to glucose, insulin, and glucagon homeostasis in humans, utilizing a hered …
Limited data are available about the role of the serotonin 2B (5-HT2B) receptor in the function of human islets. This study ai …
Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension.
West JD, Carrier EJ, Bloodworth NC, Schroer AK, Chen P, Ryzhova LM, Gladson S, Shay S, Hutcheson JD, Merryman WD. West JD, et al. PLoS One. 2016 Feb 10;11(2):e0148657. doi: 10.1371/journal.pone.0148657. eCollection 2016. PLoS One. 2016. PMID: 26863209 Free PMC article.
To test the hypothesis that a HTR2B antagonist can prevent BMRP2 mutation induced PAH by restricting aberrant SRC trafficking and downstream activity, we exposed BMPR2 mutant mice, which spontaneously develop PAH, to a HTR2B antagonist, SB204741, to block the SRC ac …
To test the hypothesis that a HTR2B antagonist can prevent BMRP2 mutation induced PAH by restricting aberrant SRC trafficking and dow …
A population-specific HTR2B stop codon predisposes to severe impulsivity.
Bevilacqua L, Doly S, Kaprio J, Yuan Q, Tikkanen R, Paunio T, Zhou Z, Wedenoja J, Maroteaux L, Diaz S, Belmer A, Hodgkinson CA, Dell'osso L, Suvisaari J, Coccaro E, Rose RJ, Peltonen L, Virkkunen M, Goldman D. Bevilacqua L, et al. Nature. 2010 Dec 23;468(7327):1061-6. doi: 10.1038/nature09629. Nature. 2010. PMID: 21179162 Free PMC article.
Here we perform exon-focused sequencing of impulsive individuals in a founder population, targeting fourteen genes belonging to the serotonin and dopamine domain. A stop codon in HTR2B was identified that is common (minor allele frequency > 1%) but exclusive to Finnish …
Here we perform exon-focused sequencing of impulsive individuals in a founder population, targeting fourteen genes belonging to the serotoni …
Serotonergic 5HTTLPR/rs25531 s-allele homozygosity associates with violent suicides in male citalopram users.
Rahikainen AL, Majaharju S, Haukka J, Palo JU, Sajantila A. Rahikainen AL, et al. Am J Med Genet B Neuropsychiatr Genet. 2017 Oct;174(7):691-700. doi: 10.1002/ajmg.b.32553. Epub 2017 Jun 13. Am J Med Genet B Neuropsychiatr Genet. 2017. PMID: 28608626
In this study, we tested the hypothesis that the genetic variants associated with decreased citalopram efficiency, 5HTTLPR/rs25531, and increased impulsive behavior, MAOA-uVNTR and HTR2B Q20*, are more frequent among citalopram users committing suicide than among the cital …
In this study, we tested the hypothesis that the genetic variants associated with decreased citalopram efficiency, 5HTTLPR/rs25531, and incr …
Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats.
Ayme-Dietrich E, Marzak H, Lawson R, Mokni W, Wendling O, Combe R, Becker J, El Fertak L, Champy MF, Matz R, Andriantsitohaina R, Doly S, Boutourlinsky K, Maroteaux L, Monassier L. Ayme-Dietrich E, et al. J Hypertens. 2015 Nov;33(11):2310-21. doi: 10.1097/HJH.0000000000000695. J Hypertens. 2015. PMID: 26259125
OBJECTIVE: Left-ventricular hypertrophy and interstitial fibrosis are the main pathophysiological factors of heart failure with preserved ejection fraction. Blockade of the serotonin 5-HT2B receptor (5-HT2BR) has been shown to reduce cardiac hypertrophy, oxidative s …
OBJECTIVE: Left-ventricular hypertrophy and interstitial fibrosis are the main pathophysiological factors of heart failure with preserved ej …
The role of 5-HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors.
Ayme-Dietrich E, Lawson R, Côté F, de Tapia C, Da Silva S, Ebel C, Hechler B, Gachet C, Guyonnet J, Rouillard H, Stoltz J, Quentin E, Banas S, Daubeuf F, Frossard N, Gasser B, Mazzucotelli JP, Hermine O, Maroteaux L, Monassier L. Ayme-Dietrich E, et al. Br J Pharmacol. 2017 Nov;174(22):4123-4139. doi: 10.1111/bph.13981. Epub 2017 Oct 15. Br J Pharmacol. 2017. PMID: 28806488 Free PMC article.
Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes.
Xu H, Wang F, Kranzler HR, Gelernter J, Zhang H. Xu H, et al. Sci Rep. 2017 Feb 6;7:41816. doi: 10.1038/srep41816. Sci Rep. 2017. PMID: 28165486 Free PMC article.

Seventy CpGs (in 41 genes) showed nominally significant associations (P < 0.05) with AD-ND codependence in both AAs and EAs. One CpG (HTR2B cg27531267) was hypomethylated in AA cases (P = 7.2 10(-5)), while 17 CpGs in 16 genes (including HTR2B cg27531267) were hy

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Seventy CpGs (in 41 genes) showed nominally significant associations (P < 0.05) with AD-ND codependence in both AAs and EAs. One CpG (

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11 results